Thinks 161

How mRNA became a vaccine game-changer: from FT. “Rossi was inspired by Shinya Yamanaka, a Japanese scientist who had proved it was possible to turn any cell in the human body into an embryonic stem cell-like state by inserting four genes. Yamanaka’s discovery eventually won him the Nobel prize. But there was a problem: the genes he inserted ended up back in the DNA, a mutagenic event that increased a person’s chance of developing cancer…Rossi’s idea was to replicate the Japanese scientist’s achievement using mRNA instead, to reprogramme human skin cells so they could act as though they were stem cells.”

Eliot Peper: “Speculative fiction is all about asking “what if?” What if a lone astronaut got stranded on Mars? What if genetic engineers resurrected dinosaurs and stuck them in an amusement park? What if we are all living in a simulation? The question that sparked my latest novel, Veil, is “what if a billionaire hijacked the climate with geoengineering?” These questions are hooks. They capture the imagination and pique curiosity. That’s all well and good, but it’s only a starting point.To pay off a speculative setup, you need to keep the dominos falling as second-, third-, and fourth-order effects ripple out through the story. Momentum builds. Progressive complications tighten the ratchet. Unexpected reversals fling the reader forward.” [Techcrunch]

Atanu Dey on systems versus goals: “goals are for losers. That’s literally true most of the time. For example, if your goal is to lose ten pounds, you will spend every moment until you reach the goal—if you reach it at all—feeling as if you were short of your goal. In other words, goal-oriented people exist in a state of nearly continuous failure that they hope will be temporary. That feeling wears on you. In time, it becomes heavy and uncomfortable. It might even drive you out of the game… In the world of dieting, losing twenty pounds is a goal, but eating right is a system. In the exercise realm, running a marathon in under four hours is a goal, but exercising daily is a system. In business, making a million dollars is a goal, but being a serial entrepreneur is a system.”

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Rajesh Jain

An Entrepreneur based in Mumbai, India.